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Photograph of Dr. Theodore Scott Nowicki.
Microscopic images of a normal heart valve in a mouse, left, and a heart valve grown in a lab with heart-derived macrophages blocked, right. Without those macrophages, the valves are thick and deformed.
Headshot of S. Thomas Carmichael in a lab coat
Research by UCLA’s Gay Crooks, Amélie Montel-Hagen and Christopher Seet could point the way toward “off-the-shelf” T cell therapies that are more readily available to patients.
Led by Dr. Donald Kohn and Katelyn Masiuk, the researchers engineered a “viral vector” that would turn on the FoxP3 gene only in regulatory T cells — and not in other types of cells.
Image shows squamous cell skin cancer tumors with lactate production (a byproduct of glucose consumption) in purple. The tumor with lactate production blocked (left) grew at the same rate as the tumor with normal lactate production (right).