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nanospears engineered for gene therapy
Researchers led by Dr. Reza Ardehali used four different fluorescent-colored proteins to determine the origin of cardiomyocytes in mice.
Left: Olig2 expression (blue) results in reduced Hes gene expression (red) and increased motor neuron formation (green) in the developing mouse spinal cord. Right: in the absence of Olig2, Hes expression increases and motor neuron formation decreases.
Dr. Joanna Gell (left) and Amander Clark examine germ cell tumor cells in the lab at UCLA.
Human embryonic stem cell-derived neurons (green) showing nuclei in blue. Left: with retinoic acid added. Right: with retinoic acid and BMP4 added, creating proprioceptive sensory interneurons (pink).
Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left).
Human heart cells grown from stem cells show less robust muscle fibers (green) in high glucose conditions (left) compared to reduced glucose conditions (right).
Microscopic image of a mini brain organoid, showing layered neural tissue and different groups of neural stem cells (in blue, red and magenta) giving rise to neurons (green).
Increasing the concentration of a certain type of BMP increases the production of the same categories of sensory interneurons (red and green). Left: no BMP added; center: 1x BMP added; right: 10x BMP added.
Untreated mouse skin showing no hair growth (left) compared to mouse skin treated with the drug UK5099 (right) showing hair growth.