CIRM Awards

All funding listed below has been awarded by the California Institute for Regenerative Medicine (CIRM), state stem cell funding agency. To date, UCLA and its stem cell scientists have received 70 grants from CIRM totaling more than $214 million.


Clinical

Alpha Stem Cell Clinics

Early Translational from Disease Team

  • Stanley Nelson, MD - Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy
  • Irvin Chen, PhD - HPSC based therapy for HIV diseases using RNAi to CCR5

Disease Team Therapy Planning I

Disease Team Therapy Development III

  • Donald Kohn, MD - Clinical Trial of Stem Cell Gene Therapy for Sickle Cell Disease
  • Dennis Slamon, MD, PhD - A Phase I dose escalation and expansion clinical trial in patients with advanced solid tumors

Disease Team Therapy Development

Disease Team Research I

  • Donald Kohn, MD - Stem Cell Gene Therapy for Sickle Cell Disease
  • Irvin Chen, PhD - HPSC based therapy for HIV diseases using RNAi to CCR5
  • Dennis Slamon, MD, PhD - Therapeutic Opportunities to Target Tumor Initiating Cells in Solid Tumors
  • Gary Steinberg, MD - Embryonic-Derived Neural Stem Cells for Treatment of Motor Sequelae following Sub-cortical Stroke

Disease Team Planning


Pre-Clinical

Early Translational Research Award IV

  • Jerome Zack, PhD - Stem Cell Programming With Chimeric Antigen Receptors to Eradicate HIV Infection
  • Donald Kohn, MD - Beta-Globin Gene Correction of Sickle Cell Disease in Hematopoietic Stem Cells
  • Gerald Lipshutz, MD - Gene therapy-corrected autologous hepatocyte-like cells from induced pluripotent stem cells for the treatment of pediatric single enzyme disorders
  • Robert Reiter, MD - Clinical Development of an N-cadherin Antibody to Target Cancer Stem Cells

Early Translational Research Award III

  • Philip Schwartz, PhD - Immune-Matched Neural Stem Cell Transplantation for Pediatric Neurodegenerative Disease

Early Translational Research Award II

Early Translational Research Award I

  • Gabriel Travis, MD - Development of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration

New Faculty Physician Scientist

  • Ali Nsair, MD - Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy
  • Reza Ardehali, MD, PhD - Preclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors

Stem Cell Transplantation Immunology Award

Tissue Collection for Disease Modeling

  • Brigitte Gomperts, MD - Using human induced pluripotent stem cells to improve our understanding of Idiopathic Pulmonary Fibrosis

Basic Science

Basic Biology Awards V

Basic Biology Awards IV

  • Owen Witte, MD - Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells
  • Kathrin Plath, PhD - Understanding the status of the X chromosomes in humanESCs and preimplantation embryos

Basic Biology Awards III

  • Kathrin Plath, PhD - Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells
  • Shuo Lin, PhD - Etsrp/ER71 mediated stem cell differentiation into vascular lineage
  • Gay Crooks, MBBS - Forming the hematopoietic Niche from Human Pluripotent Stem Cells
  • Ali Nsair, MD - Characterization and Engineering of the Cardiac Stem Cell Niche
  • W. Robb MacLellan, MD - Characterization and Engineering of the Cardiac Stem Cell Niche
  • William Lowry, PhD - Molecular determinants of accurate differentiation from human pluripotent stem cells
  • Yi Sun, PhD - Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo

Basic Biology Awards II

  • Benhur Lee, MD - The EphrinB2/EphB4 axis in regulating hESC pluripotency and differentiation
  • Douglas Black, PhD - Programs of alternative splicing regulation by polypyrimidine tract binding protein
  • Yong Kim, PhD - Novel Mechanism in Self-Renewal/Differentiation of Human Embryonic Stem Cells

Basic Biology Awards I

Comprehensive Grants

  • Gay Crooks, MBBS - Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC)
  • Guoping Fan, PhD - Epigenetic Gene Regulation During the Differentiation of Human Embryonic Stem Cells: Impact on Neural Repair
  • Jerome Zack, PhD - Human Embryonic Stem Cell Therapeutic Strategies to Target HIV Disease

New Cell Lines Awards

New Faculty Physician Scientist Translational Research Award

  • Reza Ardehali, MD, PhD - Preclinical Evaluation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors
  • Ali Nsair, MD - Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy

New Faculty Awards II

New Faculty Awards I

  • Leanne Jones, PhD - Characterization of mechanisms regulating de-differentiation and the re-acquisition of stem cell identity
  • Siavash Kurdistani, MD - Epigenetics in Cancer Stem Cell Initiation and Clinical Outcome
  • Hanna Mikkola, MD, PhD - Mechanisms of Hematopoietic stem cell Specification and Self-Renewal
  • Kathrin Plath, PhD - In Vitro Reprogramming of Mouse and Human Somatic Cells to an Embryonic State

Research Leadership Awards 2014

  • John Chute, MD, PhD - Niche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors

SEED Grants

  • Irvin Chen, PhD - Genetic Modification of the Human Genome to Resist HIV-1 Infection and/or Disease Progression
  • Zoran Galic, PhD - Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells
  • Siavash Kurdistani, MD - Cellular Epigenetic Diversity as a Blueprint for Defining the Identity and Functional Potential of Human Embryonic Stem Cells
  • William Lowry, PhD - Modeling Human Embryoninc Development with Human Embryonic Stem Cells
  • Michael Teitell, MD, PhD - Role of Mitochondria in Self-Renewal versus Differentiation of Human Embryonic Stem cells
  • Noriyuki Kasahara, MD, PhD - Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues
  • Hanna Mikkola, MD, PhD - Improving Microenvironments to Promote Hematopoietic Stem Cell Development from Human Embryonic Stem Cells

Training

Training Grants


Technologies and Facilities

Major Facilities

Shared Research Laboratories Grant

Tools & Technologies Awards III

  • James Dunn, MD, PhD - Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction
  • Carla Koehler, PhD - A small molecule tool for reducing the malignant potential in reprogramming human iPSCs and ESCs
  • Hanna Mikkola, MD, PhD - A suite of engineered human pluripotent stem cell lines to facilitate the generation of hematopoietic stem cells

Tools & Technologies Awards II

  • Richard Gatti, MD - Use of hiPSCs to develop lead compounds for the treatment of genetic diseases
  • Martin Martin, MD - Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders
  • S. Thomas Carmichael MD, PhD - Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke

Tools & Technologies Awards I

  • Hsian-Rong Tseng, PhD - Microfluidic Platform for Screening Chemically Defined Conditions that Facilitate Clonal Expansion of Human Pluripotent Stem Cells
  • Michael Phelps, PhD - Novel Tools and Technologies for Translational PET Imaging of Cell-based Therapies