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An artistic representation of the newly discovered trans-action by XIST, showing the X chromosome (yellow) and the extended and dispersed distribution of XIST (green) across the X chromosome and beyond, i.e. to autosomes, as seen with microscopy.
From left to right: Dr. Heather Christofk, Dr. Kathrin Plath and Dr. Aparna Bhaduri
A side by side image with Xist illustration on left and Kathrin Plath on the right
A colony of human induced pluripotent stem cells
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell).
Microscopic images of human stem cell–derived airway tissue models with cell nuclei (blue) and SARS-CoV-2 virus infected cells (green); tissue exposed to cigarette smoke (right) had 2 to 3 times more infected cells than non-exposed tissue (left).
Clockwise from top left: Luisa Iruela-Arispe, Dr. S. Thomas Carmichael, Dr. Inma Cobos, William Lowry, Kathrin Plath and Bennett Novitch.
UCLA researcher Michael Carey group photo with team
From left: senior authors Kathrin Plath and Jason Ernst and first authors Petko Fiziev and Constantinos Chronis
Left: Primed human embryonic stem cells have one active X chromosome (one red dot in each blue nucleus). Right: Naive human embryonic stem cells have two active X chromosomes (two red dots in each blue nucleus).