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The progression of a tumor can reflect not only changes in the DNA bases themselves, but also epigenetics factors that determine the DNA’s structural conformation and the factors with which it interacts.
Dr. Daniel Geschwind
Photo of Harley Kornblum, M.D., Ph.D. in the lab
Daniel Geschwind smiles for a photo in his office, books lining the walls behind him.
Researcher Daniel Geschwind smiles in his office before a bookshelf.
Melanoma cell lines can harbor BRAF gene amplification (red signal) in two remarkably different modes, as extrachromosomal DNA (ecDNA) (left) and as an intrachromosomal homogeneously staining region (HSR) (right)
A side by side image with Xist illustration on left and Kathrin Plath on the right
A colony of human induced pluripotent stem cells
Headshot of Michael Teitell
Three panel image with Daniel Geschwind,MD, PhD, Manish Butte, MD, PhD, and Bogdan Pasaniuc, PhD