
Bennett Novitch, Ph.D.
Bio
Bennett Novitch, Ph.D., seeks to understand the nervous system, the complex and intricate network made up of the brain, the spinal cord and the nerves that run through the body. Through this work, he aims to discover the underlying causes of neural birth defects, intellectual disabilities such as autism spectrum disorders and neurodegenerative disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis (also known as ALS or Lou Gehrig’s disease).
Novitch’s research seeks to identify how neural tissue is established during fetal development and how neurons form interconnected networks. This deeper understanding of fetal development will help scientists and clinicians recognize how cellular processes go awry to cause diseases or disorders. Novitch’s ultimate goal is to treat brain or spinal cord injury or disease by programming stem cells to generate neurons in a way that replicates normal development and restores lost neurological function.
Novitch’s most recent work focuses on creating simplified three-dimensional human brain tissue from stem cells. These so-called “mini brain organoids” mimic human brain growth, structure and development, making them vital to studying complex neurological diseases. These models provide clinicians and scientists with a perspective on the intricacies of the brain that has never before been available. Additionally, the ability to create hundreds to thousands of uniform mini brains that mimic disease allows scientists to screen drug candidates with unparalleled efficiency.
Novitch’s lab has already used these brain organoids to better understand how the Zika virus infects and damages fetal brain tissue and identify drugs that may block these devastating effects. Looking ahead, the Novitch lab intends to use these models to study other diseases that affect the formation of the brain or brain circuits such as epilepsy, autism and schizophrenia.
Another promising area of Novitch’s research centers on motor neurons, which control muscle movements needed for posture, walking, breathing and speaking. Motor neuron loss due to genetic defects, disease or injury can result in a range of movement disorders, paralysis, breathing problems and, in some cases, death. The Novitch lab has identified the chemical signals and gene networks that control the formation of motor neurons and applied this knowledge to direct the formation of these vital cells from pluripotent stem cells.
Novitch is now using these stem cell-derived neurons to discover the underlying causes of and investigate treatments for motor neuron disease. In addition, he is examining whether the cells might be effective in cell replacement therapies for the diseased or injured spinal cord, in which connections between the spinal cord and brain have been lost.
Novitch earned his master’s degree in medical sciences in 1993 from Harvard Medical School and his doctoral degree in biological chemistry and molecular pharmacology in 1998 from Harvard University. He completed postdoctoral training at the Center for Neurobiology and Behavior at Columbia University.
Publications
- TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoidsPublished in Stem Cell Reports on Thursday, September 29, 2022
- In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansionPublished in Cell Reports on Tuesday, July 19, 2022
- Identification of neural oscillations and epileptiform changes in human brain organoidsPublished in Nature Neuroscience on Monday, August 23, 2021
- Derivation of dorsal spinal sensory interneurons from human pluripotent stem cellsPublished in STAR Protocols on Friday, March 19, 2021
- Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical FatesPublished in Cell Reports on Tuesday, February 11, 2020
- Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomicsPublished in PLOS Biology on Thursday, February 1, 2018
- Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus InfectionPublished in Cell Reports on Tuesday, October 10, 2017
- Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal CordPublished in Neuron on Thursday, April 20, 2017
- 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse ModelPublished in Immunity on Tuesday, March 14, 2017
- Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog SignalingPublished in Developmental Cell on Thursday, April 30, 2015
- Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cellsPublished in Nature Communications on Tuesday, April 14, 2015
- Neuronal Organization: Unsticking the Cadherin CodePublished in Current Biology on Monday, December 1, 2014
- Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog SignalingPublished in Cell Reports on Thursday, January 16, 2014
- Functional Neuromuscular Junctions Formed by Embryonic Stem Cell-Derived Motor NeuronsPublished in PLOS One on Friday, May 4, 2012
- Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNSPublished in Neuron on Wednesday, April 25, 2012
- Directed Differentiation of Human‐Induced Pluripotent Stem Cells Generates Active Motor NeuronsPublished in Stem Cells on Monday, February 23, 2009
Honors & Affiliations
Honors
- Ablon Fellowship Award, 2017
- Ethel Scheibel Chair in Neuroscience in the UCLA David Geffen School of Medicine, 2016
- Pilot Project award, UCLA Clinical and Translational Sciences Institute, 2016
Affiliations
- Society for Developmental Biology
- International Society for Stem Cell Research
Funding
Novitch’s work is funded by the California Institute of Regenerative Medicine, the National Institute of Neurological Disorders and Stroke, the National Institute on Drug Abuse, the National Institute on Aging, the National Institute of Child Health and Human Development, and the UCLA Broad Stem Cell Research Center, including support from the Wendy Ablon Trust and the Steffy Family Trust.