Jason Ernst, PhD

Jason Ernst, Ph.D. 

Assistant Professor


Jason Ernst, PhD, conducts research in computational biology and bioinformatics. He develops and applies computational methods to better analyze and model high-throughput experimental data to address problems related to stem cells, epigenomics, and gene regulation.

Dr. Ernst developed a method for de novo discovery of chromatin states based on combinatorial and spatial pattern in genome-wide maps of multiple epigenomic marks. Using the chromatin states he systematically identified candidate functional elements across the genome in embryonic stem cells and other cell types. This work has had implications in interpreting disease associated non-coding variation. Dr. Ernst also has developed widely used computational tools for analyzing and modeling time series gene expression data.

Dr. Ernst joined the faculty at UCLA in the Department of Biological Chemistry in 2012. In addition to being a member of the Broad Stem Cell Research Center, he is also member of UCLA’s Jonsson Comprehensive Cancer Center and faculty in the Interdepartmental PhD Program in Bioinformatics.

Before joining UCLA, Dr. Ernst was a NSF postdoctoral fellow at MIT and affiliated with the MIT Broad Institute. He completed a doctorate in the School of Computer Science at Carnegie Mellon University and earned BS degrees in Computer Science and Mathematics from the University of Maryland College Park.