Vincent Pasque and Kathrin Plath
  • UCLA researchers have for the first time developed a method that defines many stages of reprogramming skin or blood cells into pluripotent stem cells
  • Study analyzed the reprogramming process at the single-cell level on a daily basis
  • Results determined that stages of cell change were the same across different reprogramming systems and cell types analyzed
  • Research has broad long-term impact in improving disease modeling and developing new and novel therapies for patients

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first-of-its-kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

The study was published online ahead of print in the journal Cell.

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