S. Thomas Carmichael, M.D., Ph.D.
As a member of the Broad Stem Cell Research Center, Dr. S. Thomas Carmichael investigates the mechanisms of recovery after neural injury, specifically stroke. By studying the cells and molecules that begin to repair the brain after injury, he and his colleagues hope to gain an overall understanding of brain repair and to the development of new drugs and cell therapies that will promote recovery.
Stroke is the leading cause of adult disability in the United States, with on average nearly 800,000 cases reported per year. Stroke has a devastating personal impact, taking up to 1/3 of all survivors into a nursing home or assisted living and leaving over 2/3 with residual disabilities. Through his work as both a researcher and an active clinician in neural injury and neurorehabilitation, Dr. Carmichael seeks to develop new avenues to promote recovery in stroke and other brain diseases.
Dr. Carmichael’s current research focus is on stem cell therapies that can potentially promote neural recovery and on enhancing the brain’s own limited responses to stroke to promote better recovery. His lab is exploring the normal stem cell response within the brain after neural injury. Specific molecular events enhance this endogenous stem cell response and promote recovery. Dr. Carmichael is also studying transplantation of stem or progenitor cells that can potentially repair the brain after injury. Through this line of inquiry, he hopes to facilitate stem cell transplantation as a therapeutic option and better understand how to develop novel cell based approaches to promote brain repair.
Dr. Carmichael received his medical and PhD degrees from Washington University School of Medicine in St. Louis, where he completed his neurology residency. He is professor and vice-chair of the department of Neurology at UCLA. In addition to his position as co-director of the Broad Stem Cell Research Center, he is an active member of the American Neurological Association, American Academy of Neurology, Society for Neuroscience and American Society of Neurorehabilitation.
Dr. Carmichael’s lab is funded by the National Institutes of Health, California Institute of Regenerative Medicine, American Heart Association and UCLA Broad Stem Cell Research Center.
GDF10 is a signal for axonal sprouting and functional recovery after stroke
Published October 26, 2015 - Nature Neuroscience
Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damageand inflammatory mediators
Online July 18, 2013 - Stroke
Remodeling of the Axon Initial Segment After Focal Cortical and White Matter Stroke
Online December 11, 2012 - Stroke