Owen N. Witte, M.D.
Owen Witte, M.D. is the founding director of the UCLA Broad Stem Cell Research Center. In this role, he advocates for science education funding and creates strategic partnerships that enable collaborative and multidisciplinary groups of clinicians, scientists and engineers to pursue breakthrough research with the shared goal of improving human health.
Dr. Witte has made significant scientific contributions to the understanding of human leukemias, immune disorders and epithelial cancers.
After graduating from Cornell University and earning his medical degree at Stanford, Dr. Witte did his postdoctoral fellowship at the Massachusetts Institute of Technology with Nobel laureate, David Baltimore.
Dr. Witte’s early discovery of the tyrosine kinase activity in the ABL protein and the demonstration of the BCR-ABL oncoproteins in leukemias was one of the preclinical discoveries that led to the development of Gleevec, the first targeted therapy for chronic myelogenous leukemia.
Dr. Witte also co-discovered the gene for Bruton's tyrosine kinase, a protein essential for normal B-lymphocyte development that, when mutated, causes the onset of X-linked agammaglobulinemia. This finding influenced the development of targeted drugs like Ibrutinib to treat leukemia and lymphoma.
Dr. Witte is now pursuing prostate cancer research, taking several independent approaches to pinpoint specific biologic functions of Castration Resistant Prostate Cancer with the intent to improve survival and reduce side effects for men with this aggressive and deadly disease.
Dr. Witte was recently appointed a University Professor by the University of California Board of Regents, an honor reserved for scholars of the highest international distinction. Dr. Witte is also a professor of microbiology, immunology and molecular genetics, the UCLA David Saxon Presidential Chair in Developmental Immunology and an appointed member of President Obama’s President’s Cancer Panel.
Dr. Witte’s work is funded by the National Institutes of Health, the Prostate Cancer Foundation, the W.M. Keck Foundation and the California Institute for Regenerative Medicine.
Phosphoproteome integration reveals patient-specific networks in prostate cancer
August 11, 2016 - Cell
N-Myc drives neuroendcrine prostate cancer initiated from human prostate epithelial cells
April 11, 2016 - Cancer Cell
Functional screen identifies kinases driving prostate cancer visceral and bone metastasis
November 4, 2015 - Proceedings of the National Academy of Sciences
A basal stem cell signature identifies aggressive prostate cancer phenotypes
September 11, 2015 - Proceedings of the National Academy of Sciences