Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

Gianni Carraro, Justin Langerman, Shan Sabri, Zareeb Lorenzana, Arunima Purkayastha, Guangzhu Zhang, Bindu Konda, Cody J. Aros, Ben A. Calvert, Aleks Szymaniak, Emily Wilson, Michael Mulligan, Priyanka Bhatt, Junjie Lu, Preethi Vijayaraj, Changfu Yao, David W. Shia, Andrew J. Lund, Edo Israely, Tammy M. Rickabaugh, Jason Ernst, Martin Mense, Scott H. Randell, Eszter K. Vladar, Amy L. Ryan, Kathrin Plath, John E. Mahoney, Barry R. Stripp & Brigitte N. Gomperts

Thursday, May 6, 2021
Published in Nature Medicine
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell). | Credit: Nature Medicine