Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

Andreas Sanger, Zachary B. Gaber, Julien Delile, Jennifer H. Kong, David L Rousso, Caroline A. Pearson, Steven E. Weicksel, Manuela Melchionda, S. Neda Mousavy Gharavy, James Briscoe and Bennett G. Novitch

Thursday, February 1, 2018
Published in PLOS Biology
cellular comparison image showing study results
Left: Olig2 expression (blue) results in reduced Hes gene expression (red) and increased motor neuron formation (green) in the developing mouse spinal cord. Right: in the absence of Olig2, Hes expression increases and motor neuron formation decreases.