The cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair

Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons Lusis, Thomas G. Graeber, Caius G. Radu, and Arjun Deb

Tuesday, November 23, 2021
Published in Journal of Clinical Investigation
side-by-side comparison of microscopic images of heart tissue
Microscopic images showing heart tissue in mice (with cardiac muscle cells in red) after a heart attack. Untreated tissue (left) shows less DNA damage (green) than tissue that has been treated with an experimental drug (right).