Matteo Pellegrini, PhD

Matteo Pellegrini, PhD 



Matteo Pellegrini, PhD, combines statistics, computer science, biology, and genetics to better understand stem cells. His research focuses on the development of computational approaches to interpret genomic data that allow him to develop large-scale models of transcriptional and epigenetic regulation.

Using the latest generation of DNA high-throughput sequencers, Dr. Pellegrini focuses on developing both low-and high-level analyses of varied data. His goal is to make these tools, and the databases that result from the sequence data, available to the scientific community at UCLA and beyond.

With his lab’s focus on bioinformatics - the application of statistics and computer science to the field of molecular biology – Dr. Pellegrini collaborates with many scientific teams at UCLA involved in genomic research. His lab was one of the first to sequence a human embryonic stem cell in order to uncover its DNA methylation profile, a crucial component of its epigenome.

Dr. Pellegrini hopes the ability to determine genome-wide profiles of embryonic stem cells, and cells reprogrammed to have the same abilities as embryonic stem cells, will result in new and more efficient reprogramming techniques and an improved ability to manipulate the cells for potential clinical uses.

In addition to his affiliation with the Broad Stem Cell Research Center, Dr. Pellegrini is a member of UCLA’s Jonsson Comprehensive Cancer Center, the ACCESS program, the California Nanosystems Institute and the Institute for Genomics and Proteomics. A professor of Molecular, Cell and Developmental Biology, Dr. Pellegrini earned his doctorate at Stanford in 1996. He joined the UCLA faculty from Merck and Company in 2005. He is also a co-director of the Broad Stem Cell Research Center’s biosequencing core.

Dr. Pellegrini’s work is funded by the National Science Foundation, the Air Force Office of Scientific Research, the Department of Energy and the National Institutes of Health.