Biophotonic Laser-Assisted Cell Surgery Tool (BLAST)

Facilities Technologies

Co-invented by Drs. Michael Teitell and Eric Pei-Yu Chiou, BLAST provides the capability to introduce molecules, bacteria and other small material into pluripotent and adult stem cells. The BLAST technique employs laser pulses to create a hole in the plasma membrane of a cell and facilitates the transport of external materials inside the cell. Drs. Teitell and Chiou expect that they will soon be able to transfer whole human chromosomes into a cell and its nuclei (to enable the creation of patient specific embryonic stem cells through somatic cell nuclear transfer). The BLAST technology, therefore, will be instrumental for modeling disease, gene regulation, and the transfer of immune recognition molecules. BLAST can potentially overcome major hurdles in engineering stem cell models for various disease states.