Intramural Awards

Made possible by philanthropic donations, the Broad Stem Cell Research Center has created the following internal research awards and professional development programs.

Broad Stem Cell Research Center Innovation Award

Gay Crooks, MD, Tatiana Segura, PhD and Zoran Galic, PhD - Generating human thymic organoids from pluripotent stem cells.
Utpal Banerjee, PhD, - Determining the mechanism by which glucose regulates differentiation in early mouse embryos.

Amander Clark, PhD, Douglas Black, PhD and Stephen Clarke, PhD - A unique RNA splicing module safeguards ESC quality
Hanna Mikkola, MD, PhD, Luisa Iruela-Arispe, MD, PhD and Zoran Galic, PhD - Hormonal Regulation of Hematopoietic Stem Cell Development
Bennett Novitch, PhD and Tatiana Segura, PhD - Organoid Modeling of Human Brain Development and Neurodevelopmental Disorders
Kathrin Plath, PhD, Jason Ernst, PhD and Sriram Kosuri- Understanding the combinatorial logic of gene regulation in pluripotent cells

Steve Jacobsen, PhD and Amander Clark, PhD - Safeguarding transposon silencing in stem cells
Donald Kohn, MD - Stem Cell Programming for Immunotherapy

Daniel Geschwind, MD, PhD - Modeling autism in human neural progenitors as a platform for therapeutic discovery
Kathrin Plath, PhD - Deciphering the role of endocytic proteins in transcriptional control of pluripotency and cell fate changes during reprogramming and differentiation

David Brooks, PhD - Hematopoietic stem cell imprinting by the intestinal microbiome
Sivash Kurdistani, MD - Role of a pseudogene in linking chromatin to hESC biology
William Lowry, PhD - Rational Design of Cell Fate Induction Modules

John Adams, MD - Using Nell-1 to Harness the Osteogenic Potential of Bone Marrow Stem Cells
Michael Teitell, MD, PhD - A Plasmonic Photothermal Nanoblade for Large Cargo Transfer into Stem Cells

Utpal Banerjee, PhD - Mitochondrial regulation of self-renewal and differentiation potential of hESCs
Kathrin Plath, PhD - Imaging the Activation of Pluripotency Genes during the Establishment of iPS Cells

Hanna Mikkola, MD, PhD - Molecular interactions in a human hematopoietic stem cell niche
Steven Jacobsen, PhD and Matteo Pellegrini, PhD - Determination of DNA methylation in human embryonic stem cells at single nucleotide resolution

Broad Stem Cell Research Center Research Award

Samantha Butler, PhD - Developing reagents to accelerate peripheral nerve regeneration
Harley Kornblum, MD, PhD, Bennett Novitch, PhD - Pathogenesis and treatment in a stem cell based model of autism
Sivash Kurdistani, MD, PhD - Defining Origins of DNA Replication that Function Uniquely in Human ESCs

Reza Ardehali, MD, PhD, Luisa Iruela-Arispe, MD, PhD, Brigitte Gomperts, MD and Benjamin Wu, DDS, PhD- Growing vascularized cardiopulmonary tissue from stem cells
S. Thomas Carmichael, MD, PhD - Stem Cell Therapy for Intracerebral Hemorrhage
Leanne Jones, PhD and Martin Martin, MD- Age-related loss of barrier function as a driver of intestinal disease
William Lowry, PhD, Xinshu Xiao, PhD and Stephen Smale, PhD - A molecular study of function and dysfunction in human neural development
Carrie Miceli, PhD, April Pyle, PhD, Rachel Crosbie-Watson, PhD, Stanley Nelson, MD and Melissa Spencer,PhD - Stem Cell Approaches for Combination DMD Exon Skipping Therapy
Benjami Wu, DDS, PhD, William Tawil, MSc, PhD and Gay Crooks, MBBS - Non-Viral Strategy for Generation of Hematopoietic Stem Cells

Heather Christofk, PhD, William Lowry, PhD and Amy Rowat, PhD - Improved pluripotent differentiation by integrating the transcriptome, metabolome and mechanome
Reza Ardehali, MD, PhD, Hanna Mikkola, MD, PhD, Ali Nsair, MD and Atsushi Nakano, MD, PhD - Heart regeneration by endocardial-derived cardiac progenitors
Michael Carey, PhD - HP1gamma Promotes ESC Differentiation by Altering Mediator
Denis Evseenko, MD, PhD - Regulation of hESC-derived chondrocyte survival by pericytes
Cun-Yu Wang, DDS, PhD - Epigenetic Regulation of Human Mesenchymal Stem Cell Self-Renewal and Properties
Yi Xing, PhD - Alternative splicing network of induced pluripotent stem cells

Amander Clark, PhD - Establishing Histone H2A ubiquitination as a master regulator of the naive stem cell state
Gay Crooks,MB, BS - Programming hematopoiesis During Mesodermal Differentiation of human Pluripotent Stem Cells
Michael Grunstein, PhD - The function of histone H3 K56 acetylation in directly recruiting Oct4 and in pluripotency
Bahram Jalali, PhD - High Throughput Fluorescent Microscope
Hanna Mikkola, MD, PhD - Defining the molecular machinery required for generating self-renewing HSC
Bennett Novitch, PhD - Functional analysis of neuromuscular synapses formed by stem cell-derived motor neurons
Lawrence Zipursky, PhD - Towards Replacement Therapy for Blindness: Integrating Photoreceptor Neurons into Retina Circuits

Irvin Chen, PhD - Deriving HIV-1 Specific Antibodies with Novel Effector Activities Through B-Cell Reprogramming
Harvey Herschman, PhD - The role of COX-2 in mouse and human ESC and iPSC teratoma formation, and in mouse and human reprogramming
Luisa Iruela-Arispe, PhD - Vascularized Organoids for Transplantation
Donald Kohn, MD - Combined Site-Specific and Selective Methods for Precise Genetic Engineering of Stem Cells
Lawrence Zipursky, PhD - Towards a Stem Cell Based Therapy for Blindness: Understanding the Molecular Basis of Connection Between Photoreceptor Neurons and Bipolar Cells

Amander Clark, PhD - Building Gonadal Niches to Functionalize Murine Pluripotent Stem Cell Derived Germ Cells
Guoping Fan, PhD - A Novel Protein Delivery Platform to Improve Cell Reprogramming & Differentiation
James Gimzewski, PhD - Chemo-Mechanical Force Induction of Stem Cell Fate Decisions
Sanaz Memarzadeh, MD, PhD - Role of Endometrial Stem & Progenitor Cells in Initiation of Type I vs. II Endometrial Carcinoma
William Lowry, PhD - A New Approach to Understanding Human Development

Arnold Berk, MD - Transduction of Human HSCs with an Ad-EBV hybrid vector
Gay Crooks, MBBS - Isolation and Manipulation of human Embryonic Mesodermal Progenitors
Harley Kornblum, MD, PhD - A Discovery-based approach for Brain Tumor Stem Cell Markers
Hong Wu, MD, PhD - Development of A Fully Chemically Defined hES Cell Culture System

Amander Clark, PhD - Genetic and epigenetic regulators of cancer stem cell self-renewal in vivo
Michael Teitell, MD, PhD - A Biophotonic Laser-Assisted cell Surgery Tool (BLAST) for manipulating hES cells

Scholars in Translational Medicine Program

Reza Ardehali, MD, PhD - Clonal analysis of cardiomyocytes renewal during normal development and after injury
Pascal Egea, PhD - Structure-Based Delivery and Design of Novel Antimalarials

Daniel Kahn, MD, PhD - Transferable Immune Tolerance through Pregnancy Enhanced Functional T Regulatory Cells
Roger Lo, MD, PhD - A microfluidic diagnostic platform guiding the treatment of melanomas with acquired resistance to B-RAF inhibition
Isaac Yang, MD - Targeting the Immune System Against Glioblastoma Stem Cell Marker CD133

Arnold Chin, MD, PhD - Optimization for Tumor Vaccines: Understanding Innate Immune Mechanisms for Antigen Specific Immunity - Influence of the Src pathway on pancreatic cancer progression
Tim Donahue, MD - Influence of the Src pathway on pancreatic cancer progression
Sanaz Memarzadeh, MD, PhD - Predictors of response to progesterone therapy in endometrial cancer initiating cells
Nader Pouratian, MD - Optimizing signal analysis and classification for real-time multidimensional BCI

CalTech-UCLA Joint Center for Translational Medicine (JCTM) Translational Acceleration Grant (TAG) Award

Marie-Francoise Chesselet, MD, PhD - Neuroprotection in Early-stage Parkinson's Disease by Nicotine-receptor Interactions; Target Identification and Mechanism of Action
Jane Deng, MD - Alterations in the Nasal Microbiome Following Influenza Infections
Itzhak Fried, MD, PhD - Using Electric Fields to Control Epileptic Seizures
Thomas Graeber, PhD - Phospho-proteomic Profiling to Define Uncharacterized Mechanisms of Resistance to BRAF in Patients with Metastatic Melanoma
Jiaoti Huang MD, PhD - Tissue Biomarkers to Predict the Risk of Prostate Cancer in Patients with Increased PSA and Negative Prostate Biopsies
Bahram Jalali, PhD - Integration of Imaging Flow Cytometry with PCR Technology for High Throughput Screening of Complex Biological Fluid
Daniel Kahn, MD, PhD - Pregnancy Enhanced T Regulatory Cell Function to Treat Autoimmune Disease
Kathleen Sakamoto, MD, PhD - Exploring Aneuploidy for Cancer Therapy
John Timmerman, MD - Toll-like Receptor 7 Agonist-antibody Conjugates for the Treatment of Cancer

David Eisensberg, PhD - An inexpensive, vaginally applied preventative for sexual transmission of HIV
Roger Lo, MD, PhD - Rational targeting of B-RAF inhibitor-resistant melanomas
Sherie Morrison, PhD - Antibody-Interferon Fusion Proteins for Cancer Treatment
Caius Radu, MD - Novel immunotherapies against chemotherapy refractory ovarian cancer