Intramural Awards

2015
Gay Crooks, MD, Tatiana Segura, PhD and Zoran Galic, PhD - Generating human thymic organoids from pluripotent stem cells.
Utpal Banerjee, PhD, - Determining the mechanism by which glucose regulates differentiation in early mouse embryos.

2014
Amander Clark, PhD, Douglas Black, PhD and Stephen Clarke, PhD - A unique RNA splicing module safeguards ESC quality
Hanna Mikkola, MD, PhD, Luisa Iruela-Arispe, MD, PhD and Zoran Galic, PhD - Hormonal Regulation of Hematopoietic Stem Cell Development
Bennett Novitch, PhD and Tatiana Segura, PhD - Organoid Modeling of Human Brain Development and Neurodevelopmental Disorders
Kathrin Plath, PhD, Jason Ernst, PhD and Sriram Kosuri- Understanding the combinatorial logic of gene regulation in pluripotent cells

2013
Steve Jacobsen, PhD and Amander Clark, PhD - Safeguarding transposon silencing in stem cells
Donald Kohn, MD - Stem Cell Programming for Immunotherapy

2012
Daniel Geschwind, MD, PhD - Modeling autism in human neural progenitors as a platform for therapeutic discovery
Kathrin Plath, PhD - Deciphering the role of endocytic proteins in transcriptional control of pluripotency and cell fate changes during reprogramming and differentiation

2011
David Brooks, PhD - Hematopoietic stem cell imprinting by the intestinal microbiome
Sivash Kurdistani, MD - Role of a pseudogene in linking chromatin to hESC biology
William Lowry, PhD - Rational Design of Cell Fate Induction Modules

2010
John Adams, MD - Using Nell-1 to Harness the Osteogenic Potential of Bone Marrow Stem Cells
Michael Teitell, MD, PhD - A Plasmonic Photothermal Nanoblade for Large Cargo Transfer into Stem Cells

2009
Utpal Banerjee, PhD - Mitochondrial regulation of self-renewal and differentiation potential of hESCs
Kathrin Plath, PhD - Imaging the Activation of Pluripotency Genes during the Establishment of iPS Cells

2008
Hanna Mikkola, MD, PhD - Molecular interactions in a human hematopoietic stem cell niche
Steven Jacobsen, PhD and Matteo Pellegrini, PhD - Determination of DNA methylation in human embryonic stem cells at single nucleotide resolution

Broad Stem Cell Research Center Research Award

2015
Samantha Butler, PhD - Developing reagents to accelerate peripheral nerve regeneration
Harley Kornblum, MD, PhD, Bennett Novitch, PhD - Pathogenesis and treatment in a stem cell based model of autism
Sivash Kurdistani, MD, PhD - Defining Origins of DNA Replication that Function Uniquely in Human ESCs

2014
Reza Ardehali, MD, PhD, Luisa Iruela-Arispe, MD, PhD, Brigitte Gomperts, MD and Benjamin Wu, DDS, PhD- Growing vascularized cardiopulmonary tissue from stem cells
S. Thomas Carmichael, MD, PhD - Stem Cell Therapy for Intracerebral Hemorrhage
Leanne Jones, PhD and Martin Martin, MD- Age-related loss of barrier function as a driver of intestinal disease
William Lowry, PhD, Xinshu Xiao, PhD and Stephen Smale, PhD - A molecular study of function and dysfunction in human neural development
Carrie Miceli, PhD, April Pyle, PhD, Rachel Crosbie-Watson, PhD, Stanley Nelson, MD and Melissa Spencer,PhD - Stem Cell Approaches for Combination DMD Exon Skipping Therapy
Benjami Wu, DDS, PhD, William Tawil, MSc, PhD and Gay Crooks, MBBS - Non-Viral Strategy for Generation of Hematopoietic Stem Cells

2013
Heather Christofk, PhD, William Lowry, PhD and Amy Rowat, PhD - Improved pluripotent differentiation by integrating the transcriptome, metabolome and mechanome
Reza Ardehali, MD, PhD, Hanna Mikkola, MD, PhD, Ali Nsair, MD and Atsushi Nakano, MD, PhD - Heart regeneration by endocardial-derived cardiac progenitors
Michael Carey, PhD - HP1gamma Promotes ESC Differentiation by Altering Mediator
Denis Evseenko, MD, PhD - Regulation of hESC-derived chondrocyte survival by pericytes
Cun-Yu Wang, DDS, PhD - Epigenetic Regulation of Human Mesenchymal Stem Cell Self-Renewal and Properties
Yi Xing, PhD - Alternative splicing network of induced pluripotent stem cells

2012
Amander Clark, PhD - Establishing Histone H2A ubiquitination as a master regulator of the naive stem cell state
Gay Crooks,MB, BS - Programming hematopoiesis During Mesodermal Differentiation of human Pluripotent Stem Cells
Michael Grunstein, PhD - The function of histone H3 K56 acetylation in directly recruiting Oct4 and in pluripotency
Bahram Jalali, PhD - High Throughput Fluorescent Microscope
Hanna Mikkola, MD, PhD - Defining the molecular machinery required for generating self-renewing HSC
Bennett Novitch, PhD - Functional analysis of neuromuscular synapses formed by stem cell-derived motor neurons
Lawrence Zipursky, PhD - Towards Replacement Therapy for Blindness: Integrating Photoreceptor Neurons into Retina Circuits

2011
Irvin Chen, PhD - Deriving HIV-1 Specific Antibodies with Novel Effector Activities Through B-Cell Reprogramming
Harvey Herschman, PhD - The role of COX-2 in mouse and human ESC and iPSC teratoma formation, and in mouse and human reprogramming
Luisa Iruela-Arispe, PhD - Vascularized Organoids for Transplantation
Donald Kohn, MD - Combined Site-Specific and Selective Methods for Precise Genetic Engineering of Stem Cells
Lawrence Zipursky, PhD - Towards a Stem Cell Based Therapy for Blindness: Understanding the Molecular Basis of Connection Between Photoreceptor Neurons and Bipolar Cells

2010
Amander Clark, PhD - Building Gonadal Niches to Functionalize Murine Pluripotent Stem Cell Derived Germ Cells
Guoping Fan, PhD - A Novel Protein Delivery Platform to Improve Cell Reprogramming & Differentiation
James Gimzewski, PhD - Chemo-Mechanical Force Induction of Stem Cell Fate Decisions
Sanaz Memarzadeh, MD, PhD - Role of Endometrial Stem & Progenitor Cells in Initiation of Type I vs. II Endometrial Carcinoma
William Lowry, PhD - A New Approach to Understanding Human Development

2009
Arnold Berk, MD - Transduction of Human HSCs with an Ad-EBV hybrid vector
Gay Crooks, MBBS - Isolation and Manipulation of human Embryonic Mesodermal Progenitors
Harley Kornblum, MD, PhD - A Discovery-based approach for Brain Tumor Stem Cell Markers
Hong Wu, MD, PhD - Development of A Fully Chemically Defined hES Cell Culture System

2008
Amander Clark, PhD - Genetic and epigenetic regulators of cancer stem cell self-renewal in vivo
Michael Teitell, MD, PhD - A Biophotonic Laser-Assisted cell Surgery Tool (BLAST) for manipulating hES cells

Scholars in Translational Medicine Program

2012
Reza Ardehali, MD, PhD - Clonal analysis of cardiomyocytes renewal during normal development and after injury
Pascal Egea, PhD - Structure-Based Delivery and Design of Novel Antimalarials

2011
Daniel Kahn, MD, PhD - Transferable Immune Tolerance through Pregnancy Enhanced Functional T Regulatory Cells
Roger Lo, MD, PhD - A microfluidic diagnostic platform guiding the treatment of melanomas with acquired resistance to B-RAF inhibition
Isaac Yang, MD - Targeting the Immune System Against Glioblastoma Stem Cell Marker CD133

2010
Arnold Chin, MD, PhD - Optimization for Tumor Vaccines: Understanding Innate Immune Mechanisms for Antigen Specific Immunity - Influence of the Src pathway on pancreatic cancer progression
Tim Donahue, MD - Influence of the Src pathway on pancreatic cancer progression
Sanaz Memarzadeh, MD, PhD - Predictors of response to progesterone therapy in endometrial cancer initiating cells
Nader Pouratian, MD - Optimizing signal analysis and classification for real-time multidimensional BCI

CalTech-UCLA Joint Center for Translational Medicine (JCTM) Translational Acceleration Grant (TAG) Award