microscope with a computer screen in the background

The Broad Stem Cell Research Center – CIRM Major Facility is located on the 3rd floor of the Terasaki Life Science Building and is less than a five minute walk from any campus laboratory, including biology, chemistry, engineering, medicine, and clinical/translational research programs. This state-of-the-art facility includes research labs, core facilities, and space for all faculty to work side by side on a wide range of stem cell research endeavors.

Good Manufacturing Practice (GMP) Facilities

UCLA Human Gene and Cell Therapy Facility (HGCTF) supports manufacturing of gene and cell therapy products for UCLA investigators as well as other academic and industry partners conducting clinical trials in which a cell or gene therapy product is manufactured under an FDA IND. This facility is a joint effort of the UCLA David Geffen School of Medicine, the Human Gene and Cell Therapy Program (HGCTP), the Jonsson Comprehensive Cancer Center, and the Broad Stem Cell Research Center.

The HGCTF is a 2,395 square foot Biosafety level 2 contained area with seven HEPA-filtered rooms (ISO 7/Class 10,000).

  • 4 positive pressure rooms designed for ex vivo manipulation of cells to minimize the possibility of outside pathogen contamination.
  • 3 negative pressure rooms for gene transfer procedures, and ensure that the recombinant vectors do not contaminate the surrounding environment.
  • Aseptic processing is carried out in biosafety cabinets (ISO 5/Class 100).

The overall operational plan for the facility includes: controlled access, facility cleaning, continuous monitoring of environment, air pressure and equipment, scheduled routine preventive maintenance and calibration of equipment. The quality system for the facility includes the appropriate management of out-of-specification (OOS) lab results and investigations, non-conforming materials and products, equipment and process deviations, change control, corrective and preventive actions (CAPA), product review/release, and internal audits.

Pricing varies and is based on the scope of work. Investigators planning to utilize the HGCTF for future research studies should include anticipated HGCTF costs in new grant application budgets. For further information on pricing, including costs for inclusion in grant budgets, please email the HGCTF staff at gmp@mednet.ucla.edu.

HGCTF Leadership

Donald B. Kohn, MD
Medical Director
(310) 794-1964

Sujna Raval-Fernandes, PhD
(310) 794-8693